群馬大学生体調節研究所分子糖代謝制御分野

業績

Fukunaka A, Tanaka G, Kimura T, Hengphasatporn K, Saito D, Shigeta M, Shibata H, Ichinose T, Ichitaro Abe, Shimura M, Sato T, Nakagawa Y, Horii T, Hatada I, Kajimura S, Kiyonari H, Sakurai H, Shigeta Y, Watada H, Fukada T, Fujitani Y. ZIP13 regulates lipid metabolism by changing intracellular iron and zinc balance. bioRxiv 07.03.601606, (2024)[bioRxiv]
Shoji M, Ohashi T, Nagase S, Yuri H, Ichihashi K, Takagishi T, Nagata Y, Nomura Y, Fukunaka A, Kenjou S, Miyake H, Hara T, Yoshigai E, Fujitani Y, Sakurai H, Dos Santos HG, Fukada T, Kuzuhara T. Possible involvement of zinc transporter ZIP13 in myogenic differentiation. Sci Rep 14:8052 (2024)[PubMed]
Pereye OB, Nakagawa Y, Sato T, Fukunaka A, Aoyama S, Nishida Y, Mizutani W, Kobayashi N, Morishita Y, Oyama T, Kawabata-Iwakawa R, Watada H, Mizukami H, Fukuda A, Fujitani Y. Identification of Ppy-lineage cells as a novel origin of pancreatic ductal adenocarcinoma. J Pathol 263:429-441 (2024)[PubMed]
Nishiyama K, Ono M, Tsuno T, Inoue R, Fukunaka A, Okuyama T, Kyohara M, Togashi Y, Fukushima S, Atsumi T, Sato A, Tsurumoto A, Sakai C, Fujitani Y, Terauchi Y, Ito S, Shirakawa J. Protective effects of imeglimin and metformin combination therapy on b-cells in db/dbmice. Endocrinology 164:bqad095 (2023)[PubMed]
Fukunaka A, Shimura M, Ichinose T, Pereye OB, Nakagawa Y, Tamura Y, Mizutani W, Inoue R, Inoue T, Tanaka Y, Sato T, Saitoh T, Fukada T, Nishida Y, Miyatsuka T, Shirakawa J, Watada H, Matsuyama S, Fujitani Y. Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model.Sci Rep15;13(1):3484(2023)[PubMed]
Aoyama S, Nishida Y, Uzawa H, Himuro M, Kanai A, Ueki K, Ito M, Iida H, Tanida I, Miyatsuka T, Fujitani Y, Matsumoto M, Watada H.Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells.Cell Chem Biol16;S2451-9456(23)00060-0(2023)[PubMed]
Kasano-Camones CI, Takizawa M, Ohshima N, Saito C, Iwasaki W, Nakagawa Y, Fujitani Y, Yoshida R, Saito Y, Izumi T, Terawaki SI, Sakaguchi M, Gonzalez FJ, Inoue Y.PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice.J Biochemmvad005(2023)[PubMed]
Wong A, Pritchard S, Moore M, Akhaphong B, Avula N, Beetch M, Fujitani Y, Alejandro EU.Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion.J Biol Chem 299(2):102878.(2023)[PubMed]
Wakabayashi Y, Miyatsuka T, Miura M, Himuro M, Taguchi T, Iida H, Nishida Y, Fujitani Y, Watada H.STAT3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by Pdx1.Sci Rep10;12(1):21419.(2022)[PubMed]
Saito D, Nakagawa Y, Sato T, Fukunaka A, Pereye OB, Maruyama N, Watada H, Fujitani Y. Establishment of an enzyme-linked immunosorbent assay for mouse pancreatic polypeptide clarifies the regulatory mechanism of its secretion from pancreatic γ cells.PLoS One17(8):e0269958. (2022)[PubMed]
Perez-Frances M, Abate MV, Baronnier D, Scherer PE, Fujitani Y, Thorel F, Herrera PL. Adult pancreatic islet endocrine cells emerge as fetal hormone-expressing cells.Cell Rep38(7):110377(2022)[PubMed]
Suzuki L, Miyatsuka T, Himuro M, Wakabayashi Y, Osonoi S, Miura M, Katahira T, Fujitani Y, Iida H, Mizukami H, Nishida Y, Watada H.Cumulative autophagy insufficiency in mice leads to progression of β-cell failure.Biochem Biophys Res Commun611:38-45.(2022)[PubMed]
Okada A, Yamada-Yamashita M, Tominaga Y, Jo K, Mori H, Suzuki R, Ishizu M, Tamaki M, Akehi Y, Takashi Y, Koga D, Shimokita E, Tanihara F, Kurahashi K, Yoshida S, Mitsui Y, Masuda S, Endo I, Aihara KI, Kagami S, Abe M, Ferreri K, Fujitani Y, Matsuhisa M, Kuroda A.Novel method utilizing bisulfite conversion with dual amplification-refractory mutation system polymerase chain reaction to detect circulating pancreatic β-cell cfDNA. J Diabetes Investig 1140-1148. (2022) [PubMed]
Fukaishi T, Nakagawa Y, Fukunaka A, Sato T, Hara A, Nakao K, Saito M, Kohno K, Miyatsuka T, Tamaki M, Matsuhisa M, Matsuoka T, Yamada T, Watada H and Fujitani Y. Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice. Diabetologia doi: 10.1007/s00125-021-05560-x. (2021)[PubMed]
Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, Inagaki M, Tachikawa M, Fujitani Y, Okamoto Y, Oyadomari S.ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model.Mol Metab18:101338. (2021)[PubMed]
Mohan R, Jo S, Lockridge A, Ferrington DA, Murray K, Eschenlauer A, Bernal-Mizrachi E, Fujitani Y, Alejandro EU.OGT Regulates Mitochondrial Biogenesis and Function via Diabetes Susceptibility Gene Pdx1.Diabetes 30:db210468.(2021)[PubMed]
Perez-Frances M, van Gurp L, Abate MV, Cigliola V, Furuyama K, Bru-Tari E, Oropeza D, Carreaux T, Fujitani Y, Thorel F, Herrera PL.Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production.Nat Commun. 22;12:4458.(2021)[PubMed]
Tatsuoka H, Sakamoto S, Yabe D, Kabai R, Kato U, Okumura T, Botagarova A, Tokumoto S, Usui R, Ogura M, Nagashima K, Mukai E, Fujitani Y, Watanabe A, Inagaki N.Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model.iScience6;23(12):101774.(2020)[PubMed]
Uzawa H, Kohno D, Koga T, Sasaki T, Fukunaka A, Okuno T, Jo-Watanabe A, Kazuno S, Miyatsuka T, Kitamura T, Fujitani Y, Watada H, Saeki K, Yokomizo T.Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis.FASEB J34:13949-13958.(2020)[PubMed]
Aoyama S, Nishida Y, Fujitani Y, Fukunaka A, Miyatsuka T, Suzuki L, Himuro M, Yoshimori T, Watada H.Rubicon in pancreatic beta cells plays a limited role in maintaining glucose homeostasis following increased insulin resistance.Endocr J67:1119-1126.(2020)[PubMed]
Takahashi M, Miyatsuka T, Suzuki L, Osonoi S, Himuro M, Miura M, Katahira T, Wakabayashi Y, Fukunaka A, Nishida Y, Fujitani Y, Takeda S, Mizukami H, Itakura A, Watada H.Biphasic changes in β-cell mass around parturition are accompanied by increased serotonin production.Sci Rep18;10:4962. [PubMed]
Himuro M, Miyatsuka T, Suzuki L, Miura M, Katahira T, Goto H, Nishida Y, Sasaki S, Koike M, Shiota C, Gittes GK, Fujitani Y, Watada H.Cellular Autophagy in α Cells Plays a Role in the Maintenance of Islet Architecture.J Endocr Soc8;3:1979-1992. (2019)[PubMed]
Hara A, Nakagawa Y, Nakao K, Tamaki M, Ikemoto T, Shimada M, Matsuhisa M, Mizukawa H, Maruyama N, Watada H, Fujitani Y. Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide. Endocr JEJ18-0441. (2019)[J-STAGE]
Fukunaka A, Fujitani Y. Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity. Int J Mol Sci19(2):476. (2018)[PubMed]
Honda A, Komiya K, Hara A, Fukunaka A, Suzuki L, Miyatsuka T, Ogihara T, Fujitani Y, Watada H. Normal pancreatic β-cell function in mice with RIP-Cre-mediated inactivation of p62/SQSTM1. Endocr JEJ17-0333. (2017)[PubMed]
Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression. PLoS Genet13:e1006950. (2017)[PubMed]
Fujitani Y. Transcriptional regulation of pancreas development and β-cell function [Review]. Endocr J64:477-486. (2017)[PubMed]
Fujitani Y, Fujimoto S, Takahashi K, Satoh H, Hirose T, Hiyoshi T, Ai M, Okada Y, Gosho M, Mita T, Watada H. Effects of linagliptin monotherapy compared with voglibose on postprandial blood glucose responses in Japanese patients with type 2 diabetes: Linagliptin Study of Effects on Postprandial blood glucose (L-STEP). Diabetes Res Clin Pract121:146-156 (2016)[PubMed]
Yamaguchi H, Arakawa S, Kanaseki T, Miyatsuka T, Fujitani Y, Watada H, Tsujimoto Y, Shimizu S. Golgi membrane-associated degradation pathway in yeast and mammals. EMBO J35:1991-2007 (2016)[PubMed]
Kakehi S, Tamura Y, Takeno K, Sakurai Y, Kawaguchi M, Watanabe T, Funayama T, Sato F, Ikeda S, Kanazawa A, Fujitani Y, Kawamori R, Watada H.Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high-fat diet. Am J Physiol Endocrinol Metab310(1):E32-40 (2016)[PubMed]
Watada H, Fujitani Y. Minireview: Autophagy in pancreatic β-cells and its implication in diabetes. Mol Endocrinol29: 338-348 (2015)[PubMed]
Sasaki S, Miyatsuka T, Matsuoka TA, Takahara M, Yamamoto Y, Yasuda T, Kaneto H, Fujitani Y, German MS, Akiyama H, Watada H, Shimomura I. Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice. Diabetologia58: 2582-2591 (2015)[PubMed]
Fujimaki K, Ogihara T, Morris DL, Oda H, Iida H, Fujitani Y, Mirmira RG, Evans-Molina C, Watada H. SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell. J Biol Chem290:16607-16618 (2015)[PubMed]
Iida H, Ogihara T, Min M, Hara A, Kim Y, Fujimaki K, Tamaki M, Fujitani Y, Kim H, Watada H. Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy. Journal of Molecular Endocrinology55: 41-53 (2015)[PubMed]
Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H. Human IAPP-induced pancreatic beta cell toxicity and its regulation by autophagy. J Clin Invest124: 3634-3644 (2014)[PubMed]
Sato T, Iwano T, Kunii M, Matsuda S, Mizuguchi R, Jung Y, Hagiwara H, Yoshihara Y, Yuzaki M, Harada R, Harada A. Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis. J Cell Sci127: 422-431 (2014)[PubMed]
Bin BH, Hojyo S, Hosaka T, Bhin J, Kano H, Miyai T, Ikeda M, Kimura-Someya T, Shirouzu M, Cho EG, Fukue K, Kambe T, Ohashi W, Kim KH, Seo J, Choi DH, Nam YJ, Hwang D, Fukunaka A, Fujitani Y, Yokoyama S, Superti-Furga A, Ikegawa S, Lee TR, Fukada T. Molecular pathogenesis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins. EMBO Mol. Med6:1028-42 (2014)[PubMed]
Yamamoto E, Uchida T, Abe H, Taka H, Fujimura T, Komiya K, Hara A, Ogihara T, Fujitani Y, Ueno T, Takeda S, Watada H. Increased expression of ERp57/GRP58 is protective against pancreatic beta cell death caused by autophagic failure. Biochem Biophys Res Commun453: 19-24 (2014)[PubMed]
Yasunari E, Mita T, Osonoi Y, Azuma K, Goto H, Ohmura C, Kanazawa A, Kawamori R, Fujitani Y, Watada H. Repetitive hypoglycemia increases circulating adrenaline level with resultant worsening of intimal thickening after vascular injury in male Goto-Kakizaki rat carotid artery. Endocrinology155: 2244-2253 (2014)[PubMed]
Tamaki M, Fujitani Y, Hara A, Uchida T, Tamura Y, Takeno K, Kawaguchi M, Watanabe T, Ogihara T, Fukunaka A, Shimizu T, Mita T, Kanazawa A, Imaizumi MO, Abe T, Kiyonari H, Hojyo S, Fukada T, Kawauchi T, Nagamatsu S, Hirano T, Kawamori R, Watada H. The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest123: 4513-4524 (2013)[PubMed]
Ishibashi K, Hara A, Fujitani Y, Uchida T, Komiya K, Tamaki M, Abe H, Ogihara T, Kanazawa A, Kawamori R, Watada H. Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice. Biochem Biophys Res Commun440: 570-575 (2013)[PubMed]
Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku Y, Ogihara T, Uchiyama Y, Yagihashi S, Fujitani Y, Watada H. Exendin-4 improves β-cell function in autophagy-deficient β-cells. Endocrinology154: 4512-4524 (2013)[PubMed]
Ohara-Imaizumi M, Kim H, Yoshida M, Fujiwara T, Aoyagi K, Toyofuku Y, Nakamichi Y, Nishiwaki C, Okamura T, Uchida T, Fujitani Y, Akagawa K, Kakei M, Watada H, German MS, Nagamatsu S. Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy. Proc Natl Acad Sci U S A110: 19420-19425 (2013)[PubMed]
Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S. PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation. Diabetes62:3459-3468 (2013)[PubMed]
Ikeda S, Tamura Y, Kakehi S, Takeno K, Kawaguchi M, Watanabe T, Sato F, Ogihara T, Kanazawa A, Fujitani Y, Kawamori R, Watada H. Exercise-induced enhancement of insulin sensitivity is associated with accumulation of M2-polarized macrophages in mouse skeletal muscle. Biochem Biophys Res Commun441:36-41 (2013)[PubMed]
Ervinna N, Mita T, Yasunari E, Azuma K, Tanaka R, Fujimura S, Sukmawati D, Nomiyama T, Kanazawa A, Kawamori R, Fujitani Y, Watada H. Anagliptin, a DPP-4 Inhibitor, Suppresses Proliferation of Vascular Smooth Muscles and Monocyte Inflammatory Reaction and Attenuates Atherosclerosis in Male apo E-Deficient Mice. Endocrinology154:1260-70 (2013)[PubMed]
Tuohetimulati G, Uchida T, Toyofuku Y, Abe H, Fujitani Y, Hirose T, Takeda S, Watada H. Effect of maternal high-fat diet on pancreatic beta cells of the offspring. Diabetology International3: 217-223 (2012)
Yorifuji T, Uchida T, Abe H, Toyofuku Y, Tamaki M, Fujitani Y, Hirose T, Kawamori R, Takeda S, Watada H. 2-Methoxyestradiol ameliorates glucose tolerance with the increase in β-cell mass in db/db mice. Journal of Diabetes Investigation2: 180-185 (2011)[PubMed]
Mita T, Azuma K, Goto H, Jin WL, Arakawa M, Nomiyama T, Suzuki R, Kubota N, Tobe K, Kadowaki T, Fujitani Y, Hirose T, Kawamori R, Watada H. IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall. Biochem Biophys Res Commun415:545-50 (2011)[PubMed]
Jin WL, Azuma K, Mita T, Goto H, Kanazawa A, Shimizu T, Ikeda F, Fujitani Y, Hirose T, Kawamori R, Watada H. Repetitive hypoglycaemia increases serum adrenaline and induces monocyte adhesion to the endothelium in rat thoracic aorta. Diabetologia54: 1921-1929 (2011)[PubMed]
Goto H, Nomiyama T, Mita T, Yasunari E, Azuma K, Komiya K, Arakawa M, Jin WL, Kanazawa A, Kawamori R, Fujitani Y, Hirose T, Watada H. Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces intimal thickening after vascular injury. Biochem Biophys Res Commun405: 79-84 (2011)[PubMed]
Tamaki M, Fujitani Y, Uchida T, Hirose T, Kawamori R, Watada H. Combination treatment of db/db mice with exendin-4 and gastrin preserves β-cell mass by stimulating β-cell growth and differentiation. J Diabetes Investigation1: 172-183 (2010)[PubMed]
Mita T, Goto H, Azuma K, Jin WL, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H. Impact of insulin resistance on enhanced monocyte adhesion to endothelial cells and atherosclerogenesis independent of LDL cholesterol level. Biochem Biophys Res Commun395: 477-483 (2010)[PubMed]
Komiya K, Uchida T, Ueno T, Koike M, Abe H, Hirose T, Kawamori R, Uchiyama Y, Kominami E, Fujitani Y, Watada H. Free fatty acids stimulate autophagy in pancreatic beta-cells via JNK pathway. Biochem Biophys Res Commun401: 561-567 (2010)[PubMed]
Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS. Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med16: 804-808, (2010)[PubMed]
Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes59: 1030-1037 (2010)[PubMed]
Toyofuku Y, Uchida T, Nakayama S, Hirose T, Kawamori R, Fujitani Y, Inoue M, Watada H. Normal islet vascularization is dispensable for expansion of beta-cell mass in response to high-fat diet induced insulin resistance. Biochem Biophys Res Commun383: 303-307 (2009)[PubMed]
Tamaki M, Fujitani Y, Uchida T, Hirose T, Kawamori R, Watada H. Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice. Islets1: 121-128 (2009)[PubMed]
Nakayama S, Uchida T, Choi JB, Fujitani Y, Ogihara T, Iwashita N, Azuma K, Mochizuki H, Hirose T, Kawamori R, Inoue M, Watada H. Impact of whole body irradiation and vascular endothelial growth factor-A on increased beta cell mass after bone marrow transplantation in a mouse model of diabetes induced by streptozotocin. Diabetologia52: 115-124 (2009)[PubMed]
Azuma K, Ichimura K, Mita T, Nakayama S, Jin WL, Hirose T, Fujitani Y, Sumiyoshi K, Shimada K, Daida H, Sakai T, Mitsumata M, Kawamori R, Watada H. Presence of alpha-smooth muscle actin-positive endothelial cells in the luminal surface of adult aorta. Biochem Biophys Res Commun380: 620-626 (2009) [PubMed]
Arakawa M, Ebato C, Mita T, Hirose T, Kawamori R, Fujitani Y, Watada H. Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents. Biochem Biophys Res Commun390: 809-814 (2009)[PubMed]
Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, Kawamori R, Fujitani Y, Watada H. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 8:325-332 (2008)[PubMed]
Inada A, Nienaber C, Katsuta H, Fujitani Y, Levine J, Morita R, Sharma A, Bonner-Weir S. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A 105:19915-19919 (2008)[PubMed]
Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol.316:74-86 (2008)[PubMed]
Arakawa M, Ebato C, Mita T, Fujitani Y, Shimizu T, Watada H, Kawamori R, Hirose T. Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects. Metabolism57: 1299-1306 (2008)[PubMed]
Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki H, Kawamori R, Watada H. Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes57: 2083-2091 (2008)[PubMed]
Motojima K, Azuma K, Kitahara Y, Miura K, Mita T, Hirose T, Fujitani Y, Kawamori R, Watada H. Repetitive postprandial hypertriglyceridemia induces monocyte adhesion to aortic endothelial cells in Goto-Kakizaki rats. Endocr J55: 373-379 (2008)[PubMed]
Nakayama S, Arakawa M, Uchida T, Ogihara T, Kanno R, Ikeda F, Azuma K, Hirose T, Kawamori R, Fujitani Y, Watada H. Dose-dependent requirement of patched homologue 1 in mouse pancreatic beta cell mass. Diabetologia 51:1883-1892 (2008)[PubMed]
Ogihara T, Fujitani Y, Uchida T, Kanno R, Choi JB, Hirose T, Kawamori R, Watada H. Combined expression of transcription factors induces AR42J-B13 cells to differentiate into insulin-producing cells. Endocr J55: 691-698 (2008)[PubMed]
Sato T, Mushiake S, Kato Y, Sato K, Sato M, Takeda N, Ozono K, Miki K, Kubo Y, Tsuji A, Harada R, Harada A. The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature 448: 366-369 (2007)[PubMed]
Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, Wright CV, Stein RW, Gannon M. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol27:4093-4104 (2007)[PubMed]
Shiraiwa T, Kaneto H, Miyatsuka T, Kato K, Yamamoto K, Kawashima A, Kajimoto Y, Matsuoka TA, Matsuhisa M, Yamasaki Y, Fujitani Y. Establishment of a non-invasive mouse reporter model for monitoring in vivo pdx-1 promoter activity. Biochem Biophys Res Commun361:739-744 (2007)[PubMed]
Yamamoto K, Miyatsuka T, Tanaka A, Toyoda S, Kato K, Shiraiwa T, Fujitani Y, Yamasaki Y, Hori M, Matsuhisa M, Matsuoka TA, Kaneto H. Tissue-specific deletion of c-Jun in the pancreas has limited effects on pancreas formation. Biochem Biophys Res Commun363:908-914 (2007)[PubMed]
Kurokawa A, Azuma K, Mita T, Toyofuku Y, Fujitani Y, Hirose T, Iwabuchi K, Ogawa H, Takeda S, Kawamori R, Watada H. 2-Methoxyestradiol Reduces Monocyte Adhesion to Aortic Endothelial Cells in Ovariectomized Rats. Endocr J54: 1027-1031 (2007)[PubMed]
Mita T, Otsuka A, Azuma K, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mitsumata M, Kawamori R,Watada H. Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun358: 679-685 (2007)[PubMed]
Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein R, Magnuson MA, Wright CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev20:253-266 (2006)[PubMed]
Miyatsuka T, Kaneto H, Shiraiwa T, Matsuoka T, Yamamoto K, Kato K, Nakamura Y, Akira S, Takeda K, Kajimoto Y, Yamasaki Y, Sandgren E, Kawaguchi Y, Wright CV, Fujitani Y. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev20:1435-1440 (2006)[PubMed]
Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol298:616-631 (2006)[PubMed]
Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, Kawaguchi Y, Edlund H, MacDonald RJ, Furukawa T, Fujikado T, Magnuson MA, Xiang M, Wright CV. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development133:4439-4450 (2006)[PubMed]
Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev20:3147-3160 (2006)[PubMed]
Tanaka A, Azuma K, Toyofuku Y, Kurokawa A, Otsuka A, Mita T, Hirosea T, Fujitani Y, Miyauchi K, Daida H, Kawamori R, Watada H. Insulin and nateglinide reduce monocyte adhesion to endothelial cells in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation. Biochem Biophys Res Commun350: 195-201 (2006)[PubMed]
Jepeal LI, Fujitani Y, Boylan MO, Wilson CN, Wright CV. Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. Endocrinology146:383-391 (2005)[PubMed]
Zhang H, Fujitani Y, Wright CV, Gannon M. Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis42:210-217 (2005)[PubMed]
Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P. Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol288:487-501 (2005)[PubMed]
Katakami N, Kaneto H, Hao H, Umayahara Y, Fujitani Y, Sakamoto K, Gorogawa S, Yasuda T, Kawamori D, Kajimoto Y, Matsuhisa M, Yutani C, Hori M, Yamasaki Y. Role of pim-1 in smooth muscle cell proliferation. J Biol Chem279:54742-54749 (2004)[PubMed]
Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Biophys Res Commun319: 1159-1170 (2004)[PubMed]
Kuroda A, Kaneto H, Fujitani Y, Watada H, Nakatani Y, Kajimoto Y, Matsuhisa M, Yamasakai Y, Fujiwara M. Mutation of the Pax6 gene causes impaired glucose-stimulated insulin secretion. Diabetologia47: 2039-2041 (2004)[PubMed]
Kawamori D, Kajimoto Y, Kaneto H, Umayahara Y, Fujitani Y, Miyatsuka T, Watada H, Leibiger IB, Yamasaki Y, Hori M. Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes52: 2896-2904 (2003)[PubMed]
Miyatsuka T, Kaneto H, Kajimoto Y, Hirota S, Arakawa Y, Fujitani Y, Umayahara Y, Watada H, Yamasaki Y, Magnuson MA, Miyazaki J, Hori M. Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun310: 1017-1025 (2003)[PubMed]
Yasuda T, Kajimoto Y, Fujitani Y, Watada H, Yamamoto S, Watarai T, Umayahara Y, Matsuhisa M, Gorogawa S, Kuwayama Y, Tano Y, Yamasaki Y, Hori M. PAX6 mutation as a genetic factor common to aniridia and glucose intolerance. Diabetes51: 224-230 (2002)[PubMed]
Umayahara Y, Kajimoto Y, Fujitani Y, Gorogawa S, Yasuda T, Kuroda A, Ohtoshi K, Yoshida Y, Kawamori D, Yamasaki Y, Hori M. Protein kinase C-dependent, CCAAT/enhancer binding protein beta-mediated expression of insulin-like growth factor I gene. J Biol Chem277:15261-15270 (2002)[PubMed]
Yoshida S, Kajimoto Y, Yasuda T, Watada H, Fujitani Y, Kosaka H, Gotow T, Miyatsuka T, Umayahara Y, Yamasaki Y, Hori M. PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. Diabetes51:2505-2513 (2002)[PubMed]
Shimajiri Y, Sanke T, Furuta H, Hanabusa T, Nakagawa T, Fujitani Y, Kajimoto Y, Takasu N, Nanjo K. A missense mutation of Pax4 gene (R121W) is associated with type2 diabetes in Japanese. Diabetes50:2864-2869 (2001)[PubMed]
Nanbu-Wakao R, Fujitani Y, Muramatsu M, Wakao H. Activation of the prolactin receptor in NIH-3T3 cells results in PPAR? expression and promotes adipogenesis. Mol Endocrinol14:307-316 (2000)
Fujitani Y, Kajimoto Y, Yasuda T, Matsuoka TA, Kaneto H, Umayahara Y, Fujita N, Watada H, Miyazaki JI, Yamasaki Y, Hori M. Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas. Mol Cell Biol19: 8281-8291 (1999)[PubMed]
Kajimoto Y, Matsuoka T, Kaneto H, Watada H, Fujitani Y, Kishimoto M, Sakamoto K, Matsuhisa M, Kawamori R, Yamasaki Y, Hori M. Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells. Diabetologia42: 1417-1424 (1999)[PubMed]
Kaneto H, Kajimoto Y, Fujitani Y, Matsuoka T, Sakamoto K, Matsuhisa M, Yamasaki Y, Hori M. Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction. Diabetologia42: 1093-1097 (1999)[PubMed]
Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Hori M. Beneficial effects of antioxidants in diabetes: Possible protection of pancreatic beta-cells against glucose toxicity. Diabetes48:2398-2406 (1999)[PubMed]
Sakamoto K, Yamasaki Y, Kaneto H, Fujitani Y, Matsuoka T, Yoshioka R, Tagawa T, Matsuhisa M, Kajimoto Y, Hori M. Identification of oxidative stress-regulated genes in rat aortic smooth muscle cells by suppression subtractive hybridization. FEBS Letters461:47-51 (1999)[PubMed]
Fujitani Y, Hibi M, Fukada T, Takahashi M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T. An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT. Oncogene14:751-761 (1997)[PubMed]
Takahashi M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T. Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK. Oncogene14:2273-2282 (1997)[PubMed]
Kajimoto Y, Watada H, Matsuoka T, Kaneto H, Fujitani Y, Miyazaki J, Yamasaki Y. Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells. J Clin Invest100: 1840-1846 (1997)[PubMed]
Matsuoka T, Kajimoto Y, Watada H, Kaneto H, Kishimoto M, Umayahara Y, Fujitani Y, Kamada T, Kawamori R, Yamasaki Y. Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J Clin Invest99: 144-150 (1997)[PubMed]
Kajimoto Y, Miyagawa J, Ishihara K, Okuyama Y, Fujitani Y, Ito M, Yoshida H, Kaisho T, Matsuoka T, Watada H, Hanafusa T, Yamasaki Y, Kamada T, Matsuzawa Y, Hirano T. Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity. Biochem Biophys Res Commun219: 941-946 (1996)[PubMed]
Watada H, Kajimoto Y, Kaneto H, Matsuoka T, Fujitani Y, Miyazaki J, Yamasaki Y. Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription. Biochem Biophys Res Commun229: 746-751 (1996)[PubMed]
Watada H, Kajimoto Y, Umayahara Y, Matsuoka T, Kaneto H, Fujitani Y, Kamada T, Kawamori R, Yamasaki Y. The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells. Diabetes45: 1478-1488 (1996)[PubMed]
Fukada T, Hibi M, Yamanaka Y, Takahashi T, Fujitani Y, Yamaguchi T, Nakajima K, Hirano T. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis.Immunity5:449-460 (1996)[PubMed]
Matsuda T, Fukada T, Takahashi M, Okuyama Y, Fujitani Y, Hanazono Y, Hirai H, Hirano T. Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer and their association. J Biol Chem270:11037-11039 (1995)[PubMed]
Matsuda T, Takahashi M, Fukada T, Okuyama Y, Fujitani Y, Tsukada S, Mano H, Hirai H, Witte ON, Hirano T. Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the Interleukin-6 family of cytokines. Blood85:627-633 (1995)[PubMed]
Fujitani Y, Nakajima K, Kojima, Nakae K, Takeda T, Hirano T. Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple STAT family proteins. Biochem Biophys Res Commun202:1181-1187 (1994)[PubMed]
Nakajima K, Kusafuka T, Takeda T, Fujitani Y, Nakae K, Hirano T. Identification of a novel interluekin-6 response element containing an Ets-binding site and a CRE-like site in the junB promoter. Mol Cell Biol13:3027-3041 (1993)[PubMed]